Discover helpful resources
and support for
Charcot-Marie-Tooth Type 4J,
better known as CMT4J,
to guide you along your journey

Discover helpful resources
and support for
Charcot-Marie-Tooth Type 4J,
better known as CMT4J,
to guide you along your journey

Charcot-Marie-Tooth Type 4J (CMT4J) is a rare subtype of Charcot-Marie-Tooth (CMT) that affects the peripheral nervous system — the nerves that lie outside the brain and spinal cord. CMT4J is caused by a genetic variant in the FIG4 gene. Common signs and symptoms in childhood include rapidly progressive muscle weakness and atrophy in the arms and legs, in addition to balance issues and numbness in the hands and feet. It is also common for a specific muscle to be affected on one side of the body and not the other, or for only part of a leg, not the entire leg. The onset, severity, and the ways that CMT4J impacts the body can vary from person-to-person. CMT4J leads to physical challenges as well as respiratory complications.

See below to discover more about CMT4J, read stories about people living with CMT4J, and learn how you or a loved one may be able to enroll in a CMT4J natural history study.

Source: Li, J. (1993). Charcot-Marie-Tooth Neuropathy Type 4J. Retrieved June 26, 2019, from link.